A randomized, double-blind, placebo-controlled pilot study to evaluate the efficacy and tolerability of a novel oral bioadhesive formulation for the treatment of nonerosive reflux disease-related symptoms

Objective The use of antisecretory drugs can provide symptomatic relief in 70–80% of patients suffering from gastro-oesophageal reflux disease (GORD), although this benefit is reduced by 20–30% in the case of nonerosive reflux disease (NERD). The current study evaluates the efficacy and safety of a patented oral formulation (liquid sachets containing hyaluronic acid, a mixture of amino acids including proline, hydroxyl-proline and glutamine, and...