Physical Activity Protects the Pathological Alterations of Alzheimer’s Disease Kidneys via the Activation of PACAP and BMP Signaling Pathways

Alzheimer's disease (AD) is a neurodegenerative disorder, with typical amyloid (Aβ) aggregations. Elimination of Aβ precursors via the kidney makes the organ a potential factor in the systemic degeneration leading to AD. PACAP exerts neuroprotective effects in AD, and plays a protective role in kidney pathologies. Increased physical activity is preventive in formation of AD but its detailed mechanism and possible connections with PACAP have not...