Monocyte Subsets With High Osteoclastogenic Potential and Their Epigenetic Regulation Orchestrated byIRF8

Volume: 36, Issue: 1, Pages: 199 - 214
Published: Sep 11, 2020
Abstract
Osteoclasts (OCs) are bone-resorbing cells formed by the serial fusion of monocytes. In mice and humans, three distinct subsets of monocytes exist; however, it is unclear if all of them exhibit osteoclastogenic potential. Here we show that in wild-type (WT) mice, Ly6Chi and Ly6Cint monocytes are the primary source of OC formation when compared to Ly6C- monocytes. Their osteoclastogenic potential is dictated by increased expression of signaling...
Paper Details
Title
Monocyte Subsets With High Osteoclastogenic Potential and Their Epigenetic Regulation Orchestrated byIRF8
Published Date
Sep 11, 2020
Volume
36
Issue
1
Pages
199 - 214
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