Metabolism

Bioinformatics

Biology

Genetics

Computational biology

Biochemistry

Trends in Endocrinology and Metabolism

The pathogenesis and development of metabolic diseases are largely affected by metabolic inflammation, or ‘metaflammation,’ which is induced by metabolism-related danger signal molecules derived from metabolic overload. We define molecules derived from excess nutrients and their metabolites, capable of inciting inflammation via activating pattern recognition receptors (PRRs), as metabolism-associated molecular patterns (MAMPs), which are a subset of damage-associated molecular pattern (DAMPs) awaiting specific classification. MAMPs interact with PRRs to incite proinflammatory signaling pathways, such as NF-κB, MAPKs, and NLRP3 inflammasome pathways, driving the production of proinflammatory mediators and contributing to the initiation and progression of metabolic diseases. Targeting MAMPs and their downstream signaling molecules might be a promising strategy for developing therapeutic approaches to metabolic diseases. Metabolic diseases pose a tremendous health threat in both developed and developing countrie...

Metabolism-Associated Molecular Patterns (MAMPs)