Size- and dose-dependent cytotoxicity of ZIF-8 based on single cell analysis

ZIF-8 nanoparticles (NPs) has been demonstrated with good potential in drug delivery, which causes an increasing attention on relevant toxicity study. In this work, MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide), glutathione (GSH), reactive oxygen species (ROS), stain analysis and gene detection assays were performed on ZIF-8 (50, 90 and 200 nm) incubated HepG2 cells. Moreover, time-resolved inductively coupled plasma mass...