Autoimmune pancreatitis - An ongoing challenge.

Published on Aug 14, 2020in Advances in Medical Sciences2.57
· DOI :10.1016/J.ADVMS.2020.07.002
Martin Blaho2
Estimated H-index: 2
(University of Ostrava),
Petr Dítě8
Estimated H-index: 8
(University of Ostrava)
+ 1 AuthorsBohuslav Kianička5
Estimated H-index: 5
(Masaryk University)
#1Sawako KurumaH-Index: 16
#2Terumi KamisawaH-Index: 60
Last. Taku TabataH-Index: 17
view all 7 authors...
Abstract Purpose To clarify the clinical characteristics of autoimmune pancreatitis (AIP) in immunoglobulin (Ig)G4-related kidney disease (IgG4-RKD). Patients and methods A total of 92 patients with AIP were divided into an IgG4-RKD-positive group (RKD-P group, n = 13) and an IgG4-RKD-negative group (RKD-N group, n = 79) on the basis of the diagnostic criteria for IgG4-RKD. Clinical characteristics, including: age; sex; the presence of extrapancreatic lesions other than renal lesions, proteinuri...
2 CitationsSource
#1Ayana Okamoto (Kindai University)H-Index: 6
#2Tomohiro Watanabe (Kindai University)H-Index: 35
Last. Masatoshi Kudo (Kindai University)H-Index: 88
view all 5 authors...
: Autoimmune pancreatitis (AIP) is now considered a pancreatic manifestation of a newly proposed disease condition, IgG4-related disease (IgG4-RD). IgG4-RD is characterized by enhanced IgG4 antibody responses and multiple organ involvements. Recent epidemiological studies have addressed the incidence of cancer in patients with AIP and/or IgG4-RD. Surprisingly, a significant number of AIP patients were detected with cancer at or within one year of the diagnosis of AIP. Furthermore, around 50% of ...
7 CitationsSource
#1Yuichi Takano (Showa University)H-Index: 4
#2Takahiro Kobayashi (Showa University)H-Index: 2
Last. Masatsugu Nagahama (Showa University)H-Index: 8
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A 66-year-old man who was on oral medication for type 2 diabetes experienced a rapid decline in glycemic control (increase in glycosylated hemoglobin level from 7.7 to 10.2% over 3 months). Abdominal ultrasonography revealed a 20-mm hypoechoic mass in the pancreatic tail. Serum tumor marker carbohydrate antigen 19–9 and DUPAN2 levels were within the respective normal ranges; serum IgG4 level was also normal at 21.8 mg/dL. Abdominal contrast computed tomography revealed a 26-mm tumor in the pancr...
2 CitationsSource
#1Matteo Tacelli (University of Palermo)H-Index: 5
#2Ciro Celsa (University of Palermo)H-Index: 7
Last. Calogero Cammà (University of Palermo)H-Index: 61
view all 9 authors...
Background & Aims Risk for relapse after induction of remission with steroid therapy has been studied extensively in patients with autoimmune pancreatitis (AIP), but findings have been equivocal. We performed a systematic review and meta-analysis to estimate the relapse rate of AIP after initial remission after steroid treatment and to identify factors associated with relapse. Methods Three reviewers searched MEDLINE, SCOPUS, and EMBASE until July 2018 to identify studies on rate of relapse of A...
9 CitationsSource
#1Hsi-Chang Shih (NTU: National Taiwan University)H-Index: 1
#2Ming-Chu Chang (NTU: National Taiwan University)H-Index: 23
Last. Yu-Ting Chang (NTU: National Taiwan University)H-Index: 25
view all 8 authors...
Misdiagnosis of autoimmune pancreatitis (AIP) as pancreatic cancer (PDAC) or vice versa can cause dismal patents’ outcomes. Changes in IgG glycosylation are associated with cancers and autoimmune diseases. This study investigated the IgG glycosylation profiles as diagnostic and prognostic biomarkers in PDAC and AIP. Serum IgG-glycosylation profiles from 86 AIP patients, 115 PDAC patients, and 57 controls were analyzed using liquid chromatography–electrospray ionization mass spectrometry. Classif...
11 CitationsSource
#1K.F. Patrick Tsang (Freeman Hospital)H-Index: 1
#2W. Kofi Oppong (Freeman Hospital)H-Index: 1
Last. K. Manu Nayar (Freeman Hospital)H-Index: 1
view all 5 authors...
Abstract Background/Objectives: Serum IgG4 level is used as a diagnostic criterion for immunoglobulin G4-related disease (IgG4-RD) but whether it predicts disease progression is unclear. Aim of the study was to investigate if serum IgG4 level at the time of diagnosis correlates with disease outcome. Methods Patients with a definitive diagnosis of IgG4-RD were included in this study. They were divided into two groups – Group 1 : Elevated serum IgG4 at diagnosis and Group 2: Normal serum IgG4 at d...
1 CitationsSource
#1Petr DiteH-Index: 15
#2Ivo NovotnyH-Index: 2
Last. Lumir Kunovsky (Masaryk University)H-Index: 5
view all 10 authors...
Background: Diagnosis of pancreatic cancer (PC) in early stages is still challenging for gastroenterologists. The early detection of cancer is one of the utmost importance for the successful therapy of this malignancy. An accurate differential diagnosis of focal pancreatic lesions plays also an important role, whether it is differential diagnosis of chronic pancreatitis from PC or autoimmune pancreatitis (AIP) from PC. Raised serum immunoglobulin G4 (IgG4) levels to twice the normal value are co...
7 CitationsSource
#1Tomohiro Watanabe (Kindai University)H-Index: 35
#2Kosuke Minaga (Kindai University)H-Index: 15
Last. Warren Strober (NIH: National Institutes of Health)H-Index: 111
view all 5 authors...
Autoimmune pancreatitis (AIP) is a pancreatic manifestation of a recently defined disease form known as IgG4-related disease (AIP/IgG4-RD). AIP/IgG4-RD is characterized by elevated systemic IgG4 antibody concentrations and lesional tissues infiltrated by IgG4-expressing plasmacytes. In addition, recent studies have revealed that, in common with other autoimmune diseases, such as systemic lupus erythematosus (SLE) and psoriasis, AIP/IgG4-RD is associated with increased type I IFN (IFN-I) producti...
21 CitationsSource
#1Nima Hafezi-Nejad (Johns Hopkins University)H-Index: 39
#1Nima Hafezi-Nejad (Johns Hopkins University)H-Index: 12
Last. Atif Zaheer (Johns Hopkins University)H-Index: 20
view all 5 authors...
: Autoimmune pancreatitis (AIP) is characterized by autoimmune inflammatory destruction of the pancreatic tissue. Imaging plays an essential role in the diagnosis. AIP type 1 is the pancreatic manifestation of immunoglobulin G4 (IgG4)-related disease and is associated with IgG4-positive plasma cell infiltration and fibrosis of multiple organ systems. Type 2 is a related disease with pancreatic inflammation with or without concurrent inflammatory bowel disease. The authors demonstrate the imaging...
7 CitationsSource
#1Sunyoung Lee (UOU: University of Ulsan)H-Index: 15
#2Jin Hee Kim (UOU: University of Ulsan)H-Index: 21
Last. Seung Soo Lee (UOU: University of Ulsan)H-Index: 29
view all 8 authors...
Objectives To intraindividually compare the diagnostic performance of CT and MRI in differentiating non-diffuse-type autoimmune pancreatitis (AIP) from pancreatic ductal adenocarcinoma (PDA).
12 CitationsSource
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