Driving CARs with alternative navigation tools – the potential of engineered binding scaffolds
Abstract
T cells that are genetically engineered to express chimeric antigen receptors (CAR T cells) have shown impressive clinical efficacy against B-cell malignancies. In contrast to these highly potent CD19-targeting CAR T cells, many of those directed against other tumor entities and antigens currently suffer from several limitations. For example, it has been demonstrated that many scFvs used as antigen-binding domains in CARs show some degree of...
Paper Details
Title
Driving CARs with alternative navigation tools – the potential of engineered binding scaffolds
Published Date
Aug 31, 2020
Journal
Volume
288
Issue
7
Pages
2103 - 2118
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