Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13

Volume: 11, Issue: 1
Published: Aug 17, 2020
Abstract
Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease in children that leads to early death. Smooth muscle cells (SMCs) are the most affected cells in HGPS individuals, although the reason for such vulnerability remains poorly understood. In this work, we develop a microfluidic chip formed by HGPS-SMCs generated from induced pluripotent stem cells (iPSCs), to study their vulnerability to flow shear stress. HGPS-iPSC SMCs...
Paper Details
Title
Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13
Published Date
Aug 17, 2020
Volume
11
Issue
1
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