Urinary CD80 Discriminates Among Glomerular Disease Types and Reflects Disease Activity

IntroductionHeterogeneity of nephrotic diseases and a lack of validated biomarkers limits interventions and reduces the ability to examine outcomes. Urinary CD80 is a potential biomarker for minimal change disease (MCD) steroid-sensitive nephrotic syndrome (NS). We investigated and validated a CD80 enzyme-linked immunosorbent assay (ELISA) in urine in a large cohort with a variety of nephrotic diseases.MethodsA commercial CD80 ELISA was enhanced...