Genetic alterations in the 3q26.31-32 locus confer an aggressive prostate cancer phenotype

Large-scale genetic aberrations that underpin prostate cancer development and progression, such as copy-number alterations (CNAs), have been described but the consequences of specific changes in many identified loci is limited. Germline SNPs in the 3q26.31 locus are associated with aggressive prostate cancer, and is the location of NAALADL2 , a gene overexpressed in aggressive disease. The closest gene to NAALADL2 is TBL1XR1 , which is...