Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy
Abstract
Inosine modulates antitumor immunity Checkpoint blockade immunotherapy harnesses the immune system to kill cancer cells and has been used with great success to treat certain tumors, but not all cancer patients respond. The efficacy of checkpoint blockade immunotherapy has been shown to depend on the presence of distinct, beneficial bacteria residing in the gut of patients, but how the microbiome mediates such beneficial effects is unclear. Mager...
Paper Details
Title
Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy
Published Date
Sep 18, 2020
Journal
Volume
369
Issue
6510
Pages
1481 - 1489
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