Polygenic Risk Scores in Alzheimer's Disease: Current Applications and Future Directions
Abstract
Genome-wide association studies have identified nearly 40 genome-wide significant single nucleotide polymorphisms (SNPs) which are associated with Alzheimer's Disease (AD). Due to the polygenicity of AD, polygenic risk scores (PRS) have shown high potential for AD risk prediction. PRSs have been shown to successfully discriminate between AD cases and controls achieving a prediction accuracy of up to 84% based on area under the receiver operating...
Paper Details
Title
Polygenic Risk Scores in Alzheimer's Disease: Current Applications and Future Directions
Published Date
Aug 11, 2020
Journal
Volume
2
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