18 F-FDG PET/CT in patients with polymyositis/dermatomyositis: correlation with serum muscle enzymes

Published on Dec 1, 2020in European Journal of Hybrid Imaging
· DOI :10.1186/S41824-020-00084-W
Hanae Arai-Okuda1
Estimated H-index: 1
,
Takashi Norikane7
Estimated H-index: 7
+ 7 AuthorsYoshihiro Nishiyama39
Estimated H-index: 39
Sources
Abstract
Muscle enzymes are the major noninvasive diagnostic parameters useful in polymyositis/dermatomyositis (PM/DM). Few studies have yet correlated findings on 18F-FDG PET with disease activity in patients with PM/DM. We evaluated 18F-FDG muscle uptake in patients with PM/DM compared with non-muscular diseases and correlated the results with serum muscle enzymes. A total of 28 patients with untreated PM/DM and 28 control patients with non-muscular diseases were examined with 18F-FDG PET/CT. 18F-FDG uptake was evaluated in 9 proximal skeletal muscle regions bilaterally. The uptake was scored as follows: 0 = less than that of the mediastinal blood vessels, 1 = greater than or equal to that of the mediastinal blood vessels, and 2 = greater than or equal to that of the liver. A score 1 or 2 was considered positive. The mean and maximum standardized uptake values (SUV) were calculated in each muscle and were averaged for all muscle regions. PET findings were correlated with serum muscle enzymes. 18F-FDG uptake was observed in 82% of patients with PM/DM and 7% of control patients. The number of positive regions, total score, mean SUVmean, and mean SUVmax in patients with PM/DM were significantly higher than those in the control patients (all P < 0.001). The total score of 2 was the best cut-off value that could discriminate patients with PM/DM from control patients. The total score, mean SUVmean, and mean SUVmax showed significant correlations with creatine kinase (P = 0.047, 0.002, 0.010, respectively) and aldolase (P = 0.036, 0.005, 0.038, respectively). 18F-FDG PET/CT using visual and SUV methods demonstrated its usefulness by discriminating PM/DM from non-muscular diseases and correlating with serum muscle enzymes in patients with PM/DM.
References13
Newest
#1Sriram VaidyanathanH-Index: 15
#2C.N. PatelH-Index: 5
Last. Fahmid U. ChowdhuryH-Index: 18
view all 4 authors...
Integrated positron emission tomography/computed tomography (PET/CT) with the glucose analogue, 2-[ 18 F]-fluoro-2-deoxy- d -glucose (FDG), is an evolving hybrid imaging technique in the evaluation of an important and diverse group of pathological conditions, which are characterised by infection and aseptic inflammation. With a rapidly expanding body of evidence, it is being increasingly recognised that, in addition to its established role in oncological imaging, FDG PET/CT also has clinical uti...
145 CitationsSource
#1Maki Tateyama (Tohoku University)H-Index: 17
#2Kazuo Fujihara (Tohoku University)H-Index: 69
Last. Masashi Aoki (Tohoku University)H-Index: 69
view all 6 authors...
Objectives [18F] Fluorodeoxyglucose positron emission tomography (FDG PET), a standard tool for evaluating malignancies, can also detect inflammatory lesions. However, its usefulness in evaluating muscle lesions in polymyositis and dermatomyositis syndromes (PM/DM) has not been established. Methods 33 patients with PM/DM who had undergone FDG PET were retrospectively analysed. FDG uptake was visually evaluated (visually identified FDG uptake, vFDG) in 16 regions of the body using mediastinum blo...
28 CitationsSource
#1Shigeru Tanaka (Chiba University)H-Index: 7
#2Kei Ikeda (Chiba University)H-Index: 27
Last. Hiroshi Nakajima (Chiba University)H-Index: 75
view all 12 authors...
Objective. This study aimed to determine whether ( 18 F)fluorodeoxyglucose-PET/CT (( 18 F)FDG-PET/CT) discriminates PM/DM from non-muscular diseases and also whether FDG uptake in proximal muscles reflects the activity and severity of muscular inflammation in PM/DM. Methods. Twenty treatment-naive PM/DM patients who underwent ( 18 F)FDG-PET/CT were retrospectively identified by reviewing medical records. The same number of age- and sex-matched control patients with non-muscular diseases were als...
41 CitationsSource
#1Takayoshi OwadaH-Index: 7
#2Reika MaezawaH-Index: 8
Last. Takeshi FukudaH-Index: 33
view all 6 authors...
Objective. To evaluate the usefulness of F-18 fluorodeoxyglucose positron emission tomography (FDG-PET) imaging in the management of patients with inflammatory myopathy. We examined whether FDG-PET scanning detects myositis or extramuscular lesions in patients with polymyositis (PM) and dermatomyositis (DM). Methods. FDG-PET imaging was performed in 24 patients with active inflammatory myopathy (PM, 11; DM, 13). The images were read by radiologists in a blinded manner. FDG uptake into muscles wa...
35 CitationsSource
OBJECTIVES: To establish whether 18FFluorodeoxyglucose (FDG) positron emission computerised tomography (FDG-PET/CT) might reveal active disease in patients with myositis. METHODS: We studied 12 patients with active myositis (2 polymyositis, 10 dermatomyositis). The controls consisted of 14 randomly chosen subjects without muscle disease. FDG uptake was expressed as the ratio of maximum proximal muscle to liver standardised uptake value. Magnetic resonance of the thigh and pelvic floor muscles wa...
27 Citations
A 55-year-old patient presented with progressive proximal tetraparesis since 2 months associated with erythematous rash and cuticular changes. Creatine kinase levels were elevated (2400 IU/l). Electromyography showed fibrillation and positive sharp wave potentials. Deltoid muscle biopsy …
4 CitationsSource
#1Martin Gotthardt (Radboud University Nijmegen Medical Centre)H-Index: 14
#2Chantal P. Bleeker-Rovers (Radboud University Nijmegen Medical Centre)H-Index: 39
Last. Wim J.G. Oyen (Radboud University Nijmegen Medical Centre)H-Index: 110
view all 4 authors...
Nuclear medicine imaging procedures play an important role in the assessment of inflammatory diseases. With the advent of 3-dimensional anatomic imaging, there has been a tendency to replace traditional planar scintigraphy by CT or MRI. Furthermore, scintigraphic techniques may have to be combined with other imaging modalities to achieve high sensitivity and specificity, and some may require time-consuming labeling procedures. On the other hand, new developments such as combined SPECT/CT increas...
188 CitationsSource
#1Ryan S. Jackson (SLU: Saint Louis University)H-Index: 16
#1Ryan S. Jackson (SLU: Saint Louis University)H-Index: 5
Last. Medhat OsmanH-Index: 24
view all 4 authors...
Recently, the use of 18 F-FDG PET has progressed rapidly as a standard diagnostic imaging tool in many types of cancer. The purpose of this study was to evaluate the patterns and prevalence of muscle uptake as a result of muscle activity shortly before the 18 F-FDG injection or during the uptake phase. Methods: From October 2002 to October 2003, whole-body 18 F-FDG PET scans (4-min emission and 3-min transmission per bed position) were performed on 1,164 patients with known or suspected malignan...
66 Citations
#1Lisa G. Rider (FDA: Food and Drug Administration)H-Index: 67
#2Frederick W. MillerH-Index: 90
Last. Frederick W. MillerH-Index: 16
view all 2 authors...
The laboratory plays an important role in the diagnosis, evaluation, and classification of the heterogeneous group of diseases known as the IIM, which are characterized by chronic muscle inflammation. Serial measurements of the levels of muscle-derived enzymes in serum are the traditional laboratory studies used to follow the clinical course of patients with IIM, although other laboratory tests can also be useful in assessing myositis disease activity. Several markers of immune system activation...
47 Citations
#1Roko Kubota (Tohoku University)H-Index: 15
#2Susumu YamadaH-Index: 18
Last. Tatsuo IdoH-Index: 53
view all 6 authors...
While2-deoxy-2-(18F)fluoro-D-glucose ((18F)FDG) is a useful tumor imagingagent,its intratumoraldistributionhasnot been described well at the cellular level. In order to demonstrate cellular localization of (18F)FDGand 2-deoxy-D-(3H)glucose (3H-DG)uptake by the tumor in vivo, C3H/He mice trans plantedsubcutaneously withFM3Atumorswerestudied1 hr after intravenousinjectionof (18F)FDG or 3H-DGusing micro and macro-autoradiography. Fluorine-i8-FDG and 3H-DG showed the same distilbution pattern in the...
1,018 Citations
Cited By0
Newest