Quantitative Fluxomics of Circulating Metabolites
Abstract
Mammalian organs are nourished by nutrients carried by the blood circulation. These nutrients originate from diet and internal stores, and can undergo various interconversions before their eventual use as tissue fuel. Here we develop isotope tracing, mass spectrometry, and mathematical analysis methods to determine the direct sources of circulating nutrients, their interconversion rates, and eventual tissue-specific contributions to TCA cycle...
Paper Details
Title
Quantitative Fluxomics of Circulating Metabolites
Published Date
Oct 1, 2020
Journal
Volume
32
Issue
4
Pages
676 - 688.e4
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Notes
History