Development of chitosan beads for controlled release of dexamethasone prepared by co-axial needle method

Preparation of dexamethasone (Dex)-loaded chitosan beads were developed applying a surface-response methodology. The operational conditions were optimized with the aim of maximizing the loading capacity of Dex. The loading of the drug within the chitosan beads was carried out by ionotropic gelation technique with tetra sodium phosphate (TSP) as cross-linking agent with co-axial method that compared with simple mixing method. The co-axial method...