TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis.

Volume: 140, Issue: 4, Pages: 513 - 534
Published: Aug 9, 2020
Abstract
Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are critical for the clearance of myelin debris in areas of demyelination, a key step to allow remyelination. TREM2 is expressed by microglia and promotes microglial survival, proliferation, and phagocytic activity. Herein we demonstrate that TREM2 was highly expressed on...
Paper Details
Title
TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis.
Published Date
Aug 9, 2020
Volume
140
Issue
4
Pages
513 - 534
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