DRP1 promotes lactate utilization in KRAS ‐mutant non‐small‐cell lung cancer cells

Volume: 111, Issue: 10, Pages: 3588 - 3599
Published: Aug 27, 2020
Abstract
Metabolic alterations are well documented in various cancers. Non-small-cell lung cancers (NSCLCs) preferentially use lactate as the primary carbon source, but the underlying mechanisms are not well understood. We developed a lactate-dependent cell proliferation assay and found that dynamin-related protein (DRP1), which is highly expressed in KRAS-mutant NSCLC, is required for tumor cells to proliferate and uses lactate as fuel, demonstrating...
Paper Details
Title
DRP1 promotes lactate utilization in KRAS ‐mutant non‐small‐cell lung cancer cells
Published Date
Aug 27, 2020
Volume
111
Issue
10
Pages
3588 - 3599
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