The newly synthesized compounds (NCHDH and NTHDH) attenuates LPS-induced septicemia and multi-organ failure via Nrf2/HO1 and HSP/TRVP1 signaling in mice

Volume: 329, Pages: 109220 - 109220
Published: Sep 1, 2020
Abstract
The sepsis is considered as serious clinic-pathological condition related with high rate of morbidity and mortality in critical care settings. In the proposed study, the hydrazides derivatives N -(benzylidene)-2-((2-hydroxynaphthalen-1-yl)diazenyl)benzohydrazides (1–2) (NCHDH and NTHDH) were investigated against the LPS-induced sepsis in rodents. The NCHDH and NTHDH markedly improved the physiological sign and symptoms associated with the sepsis...
Paper Details
Title
The newly synthesized compounds (NCHDH and NTHDH) attenuates LPS-induced septicemia and multi-organ failure via Nrf2/HO1 and HSP/TRVP1 signaling in mice
Published Date
Sep 1, 2020
Volume
329
Pages
109220 - 109220
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