Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment
Abstract
Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however, a subset of patients progress to severe disease and respiratory failure. The mechanism of protective immunity in mild forms and the pathogenesis of severe COVID-19 associated with increased neutrophil counts and dysregulated immune responses remain unclear. In a dual-center, two-cohort study, we combined single-cell RNA-sequencing and single-cell...
Paper Details
Title
Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment
Published Date
Sep 1, 2020
Journal
Volume
182
Issue
6
Pages
1419 - 1440.e23
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Notes
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