Reactive arthritis

Arthropathy

Enthesitis

Dermatology

Monoarthritis

Outpatient clinic

Enthesopathy

Psoriasis

Internal medicine

Pathology

Psoriatic arthritis

Surgery

Alternative medicine

Osteoarthritis

Arthritis

Dactylitis

Medicine

Annals of the Rheumatic Diseases

2][3] Apart from crystal-induced arthritis, 1 Yokogawa et al 2 and Alivernini et al 3 both described the onset of inflammatory arthritis with the characteristics of viral arthritis over the course of COVID-19.Here we would like to share a different case of monarthritis associated with psoriatic skin lesions presenting after resolution of SARS-CoV-2 infection.In April 2020, a patient in his 30s was admitted to our early arthritis outpatient clinic due to a 2-week history of painful limitation of the right elbow.The patient had no previous history of arthritis, back pain, enthesopathy, dactylitis, psoriasis (PsO) or other extra-articular symptoms of axial spondylarthritis, nor familiarity for rheumatic diseases and/or PsO.Forty days earlier, the patient had been suffering from arthromyalgia, fatigue, diarrhoea and anosmia, and had been diagnosed with COVID-19 based on reverse transcription (RT-PCR) detection of SARS-CoV-2 following nasopharingeal swab.Blood test analysis at the time of SARS-CoV-2 infection showed leucocytosis, lymphopaenia and increased levels of C reactive protein.The patient self-isolated and self-medicated with symptomatic drugs.COVID-19 symptoms resolved after 2 weeks, and two consecutive nasopharyngeal swabs at 3-day intervals tested negative for SARS-CoV-2.Ten days after resolution of symptoms, the patient started experiencing pain at the right elbow, together with the appearance of three itchy, clearly demarcated erythematous scaly patches on the extensor surface of both elbows and groin suggestive of PsO (figure 1A).During the following 2 weeks, pain and functional limitation of the right elbow continued to increase.The right elbow was swollen at both clinical and ultrasonographic assessments (figure 1B), and the synovial fluid was negative for SARS-CoV-2 RNA on RT-PCR and free from crystals on polarised microscopic examination.Nonsteroidal anti-inflammatory drugs for arthritis and topical steroids for skin lesions were prescribed.Six weeks later, skin and joint symptoms had completely disappeared.Blood test analysis revealed resolution of leucocytosis and lymphopaenia, with mild reduction of natural killer (NK) and CD19+ lymphocytes (104 and 125/μL, respectively), and normal values of CD4+ and CD8+ lymphocytes.Antinuclear antibodies, antiextractable nuclear antigens, rheumatoid factor and anticitrullinated protein autoantibodies all tested negative.Human leucocyte antigen B*27 and C*06 were absent.SARS-CoV-2 S1/S2 IgG title was 82.4 AU/mL, with normal values of <12 AU/mL.The possible immune mechanisms underlying the occurrence of acute arthritis following SARS-CoV-2 infection deserve further investigation.Compared with the cases of viral arthritis described to date, 2 3 our patient displayed features of reactive arthritis.In some patients with COVID-19, a state of virus-induced transient immunosuppression 4 may predispose to the occurrence of certain immune-mediated (auto)inflammatory diseases even in the absence of a genetic background.This state of immunosuppression may indeed induce an

Transient monoarthritis and psoriatic skin lesions following COVID-19