A Whole Blood Gene Expression Signature Accurately Diagnoses Multiple Myeloma and Differentiates Patients in Remission from Those with Active and Progressive Disease

Introduction: null A variety of multiple myeloma (MM) gene expression (GEP) signatures have been developed based on plasma cell transcriptomic analyses. Although generally prognostic, these have limited utility for separating overt MM from earlier stages of plasma cell dyscrasias such as monoclonal gammopathy of undetermined significance (MGUS). A disadvantage is they are invasive and require collection of plasma cells by bone marrow biopsy. We...