Lupus-like autoimmunity and increased interferon response in patients with STAT3-deficient hyper-IgE syndrome

Autosomal dominant hyper-IgE syndrome (AD-HIES) is a rare primary immunodeficiency caused by dominant negative loss-of-function (LOF) mutations in signal transducer and activator of transcription 3 (STAT3).1Holland S.M. DeLeo F.R. Elloumi H.Z. Hsu A.P. Uzel G. Brodsky N. et al.STAT3 mutations in the hyper-IgE syndrome.N Engl J Med. 2007; 357: 1608-1619Crossref PubMed Scopus (870) Google Scholar Patients with STAT3 LOF have recurrent skin and...