Modulating disease-relevant tau oligomeric strains by small molecules

Volume: 295, Issue: 44, Pages: 14807 - 14825
Published: Oct 1, 2020
Abstract
The pathological aggregation of tau plays an important role in Alzheimer's disease and many other related neurodegenerative diseases, collectively referred to as tauopathies. Recent evidence has demonstrated that tau oligomers, small and soluble prefibrillar aggregates, are highly toxic due to their strong ability to seed tau misfolding and propagate the pathology seen across different neurodegenerative diseases. We previously showed that novel...
Paper Details
Title
Modulating disease-relevant tau oligomeric strains by small molecules
Published Date
Oct 1, 2020
Volume
295
Issue
44
Pages
14807 - 14825
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