The pathophysiology of SARS-CoV-2: A suggested model and therapeutic approach.
Abstract
In this paper, a model is proposed of the pathophysiological processes of COVID-19 starting from the infection of human type II alveolar epithelial cells (pneumocytes) by SARS-CoV-2 and culminating in the development of ARDS. The innate immune response to infection of type II alveolar epithelial cells leads both to their death by apoptosis and pyroptosis and to alveolar macrophage activation. Activated macrophages secrete proinflammatory...
Paper Details
Title
The pathophysiology of SARS-CoV-2: A suggested model and therapeutic approach.
Published Date
Oct 1, 2020
Journal
Volume
258
Pages
118166 - 118166
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Notes
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