Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly
Volume: 12, Issue: 1
Published: Jan 1, 2020
Abstract
Midlife obesity is a risk factor for dementia. We investigated the impact of obesity on brain structure, metabolism, and cerebrospinal fluid (CSF) core Alzheimer's disease (AD) biomarkers in healthy elderly.We selected controls from ADNI2 with CSF AD biomarkers and/or fluorodeoxyglucose positron emission tomography (FDG-PET) and 3T-MRI. We measured cortical thickness, FDG uptake, and CSF amyloid beta (Aβ)1-42, p-tau, and t-tau levels. We...
Paper Details
Title
Obesity impacts brain metabolism and structure independently of amyloid and tau pathology in healthy elderly
Published Date
Jan 1, 2020
Volume
12
Issue
1
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