Induced pluripotent stem cell

Embryo

Somite

FGF and mesoderm formation

Intermediate mesoderm

Anatomy

Biology

Gene

Embryonic stem cell

Yolk sac

NODAL

Embryogenesis

Cell biology

Germ layer

Mesoderm

Gastrulation

Genetics

Nature Communications

Human embryogenesis is hallmarked by two phases of yolk sac development. The primate hypoblast gives rise to a transient primary yolk sac, which is rapidly superseded by a secondary yolk sac during gastrulation. Moreover, primate embryos form extraembryonic mesoderm prior to gastrulation, in contrast to mouse. The function of the primary yolk sac and the origin of extraembryonic mesoderm remain unclear. Here, we hypothesise that the hypoblast-derived primary yolk sac serves as a source for early extraembryonic mesoderm, which is supplemented with mesoderm from the gastrulating embryo. We discuss the intricate relationship between the yolk sac and the primate embryo and highlight the pivotal role of the yolk sac as a multifunctional hub for haematopoiesis, germ cell development and nutritional supply.

Origin and function of the yolk sac in primate embryogenesis