Molecular mechanisms and clinical management of cancer bone metastasis
Abstract
As one of the most common metastatic sites of malignancies, bone has a unique microenvironment that allows metastatic tumor cells to grow and flourish. The fenestrated capillaries in the bone, bone matrix, and bone cells, including osteoblasts and osteoclasts, together maintain the homeostasis of the bone microenvironment. In contrast, tumor-derived factors act on bone components, leading to subsequent bone resorption or excessive bone...
Paper Details
Title
Molecular mechanisms and clinical management of cancer bone metastasis
Published Date
Jul 29, 2020
Journal
Volume
8
Issue
1
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