DOCK5 couples CDC42-GSK3beta activation with focal adhesion morphogenesis to reinforce the establishment of polarity and promote YAP/TAZ activation during migration.

Published: Jul 24, 2020
Abstract
null YAP and TAZ are transcriptional co-activators that are often constitutively active in triple negative breast cancer (TNBC) cells. However the mechanisms responsible for YAP/TAZ dysregulation in TNBC remain unclear. We hypothesised that RhoGEF activity in TNBC cells underpins YAP/TAZ activation in TNBC cells. Through systematic RNAi screening we found that the Focal Adhesion (FA) associated RhoGEF DOCK5 promotes YAP/TAZ nuclear translocation...
Paper Details
Title
DOCK5 couples CDC42-GSK3beta activation with focal adhesion morphogenesis to reinforce the establishment of polarity and promote YAP/TAZ activation during migration.
Published Date
Jul 24, 2020
Journal
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