Rational Avoidance of Protease Cleavage Sites and Symmetrical End-Tagging Significantly Enhances the Stability and Therapeutic Potential of Antimicrobial Peptides

Antimicrobial peptides (AMPs) are expected to solve problem of antibiotic resistance because of their distinctive nonspecific membrane-disruptive mechanism. However, clinical applications of AMPs have been precluded by their poor stability, although various complex chemical strategies have been employed to solve this problem, and this undoubtedly greatly increases the manufacturing cost. Herein, a series of novel peptides with high stability...