Derivatives of 1,2,4-triazole imines acting as dual iNOS and tumor cell growth inhibitors
Abstract
A set of 4-(R2-imino)-3-mercapto-5-(R1)-4H-1,2,4-triazoles derivatives were synthesized, characterized and evaluated for their ability to inhibit nitric oxide (NO) production in PAM212 mouse keratinocytes, which led to the discovery and the subsequent evaluation of their growth inhibitory cytotoxic potency toward that same mouse cell line together with a number of human cells lines (PC3, HT-29 and HeLa). Some limited SAR could be established for...
Paper Details
Title
Derivatives of 1,2,4-triazole imines acting as dual iNOS and tumor cell growth inhibitors
Published Date
Oct 1, 2020
Journal
Volume
103
Pages
104128 - 104128
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Notes
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