Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses
Abstract
The emergence of SARS-CoV-2 and the ensuing explosive epidemic of COVID-19 disease has generated a need for assays to rapidly and conveniently measure the antiviral activity of SARS-CoV-2-specific antibodies. Here, we describe a collection of approaches based on SARS-CoV-2 spike-pseudotyped, single-cycle, replication-defective human immunodeficiency virus type-1 (HIV-1), and vesicular stomatitis virus (VSV), as well as a replication-competent...
Paper Details
Title
Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses
Published Date
Jul 21, 2020
Volume
217
Issue
11
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