Single-cell transcriptomic analysis in a mouse model deciphers cell transition states in the multistep development of esophageal cancer
Abstract
Esophageal squamous cell carcinoma (ESCC) is prevalent in some geographical regions of the world. ESCC development presents a multistep pathogenic process from inflammation to invasive cancer; however, what is critical in these processes and how they evolve is largely unknown, obstructing early diagnosis and effective treatment. Here, we create a mouse model mimicking human ESCC development and construct a single-cell ESCC developmental atlas....
Paper Details
Title
Single-cell transcriptomic analysis in a mouse model deciphers cell transition states in the multistep development of esophageal cancer
Published Date
Jul 24, 2020
Journal
Volume
11
Issue
1
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