Phase Ib Study of Wnt Inhibitor Ipafricept with Gemcitabine and nab-paclitaxel in Patients with Previously Untreated Stage IV Pancreatic Cancer

Volume: 26, Issue: 20, Pages: 5348 - 5357
Published: Jul 21, 2020
Abstract
Background: null The recombinant fusion protein ipafricept blocks Wnt signaling, and in combination with gemcitabine and nab-paclitaxel caused tumor regression in xenografts. This phase Ib study evaluated the combination of ipafricept with nab-paclitaxel + gemcitabine in patients with untreated metastatic pancreatic adenocarcinoma (mPDAC). null Patients and Methods: null Dose escalation started with standard dose nab-paclitaxel + gemcitabine and...
Paper Details
Title
Phase Ib Study of Wnt Inhibitor Ipafricept with Gemcitabine and nab-paclitaxel in Patients with Previously Untreated Stage IV Pancreatic Cancer
Published Date
Jul 21, 2020
Volume
26
Issue
20
Pages
5348 - 5357
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