Leptin Promotes Prostate Cancer Proliferation and Migration by Stimulating STAT3 Pathway.

Published on Aug 9, 2021in Nutrition and Cancer2.363
路 DOI :10.1080/01635581.2020.1792946
Amal Gorrab1
Estimated H-index: 1
(Tunis University),
Alessandra Pagano13
Estimated H-index: 13
(AMU: Aix-Marseille University)
+ 4 AuthorsAsma Gati3
Estimated H-index: 3
(Tunis University)
Sources
Abstract
To better understand the link between obesity and prostate cancer (PC) aggressiveness, we investigate the role of leptin, an obesity associated adipokine, and its receptor (Ob-R) in PC cells migrat...
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References44
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#1Ahmad Ghasemi (IUMS: Isfahan University of Medical Sciences)H-Index: 10
#2Jafar Saeidi (IAU: Islamic Azad University)H-Index: 5
Last. Seyed Isaac Hashemy (MUMS: Mashhad University of Medical Sciences)H-Index: 18
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Background Increasing evidence indicates that obesity is associated with tumor development and progression. Leptin is an adipocyte-related hormone with a key role in energy metabolism and whose circulating levels are elevated in obesity. The effect of leptin on cancer progression and metastasis and its underlying mechanisms are still unclear. Leptin can impact various steps in tumor metastasis, including epithelial-mesenchymal transition, cell adhesion to the extracellular matrix (ECM), and prot...
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#1Sebastiano And貌 (University of Calabria)H-Index: 76
#2Luca Gelsomino (University of Calabria)H-Index: 14
Last. Stefania Catalano (University of Calabria)H-Index: 42
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The prevalence of obesity has been steadily increasing over the past few decades in several developed and developing countries, with resultant hazardous health implications. Substantial epidemiological evidence has shown that excessive adiposity strongly influences risk, prognosis, and progression of various malignancies, including breast cancer. Indeed, it is now well recognized that obesity is a complex physiologic state associated with multiple molecular changes capable of modulating the beha...
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#1Jinyong He (CPU: China Pharmaceutical University)H-Index: 5
#2Xiaohui Wei (CPU: China Pharmaceutical University)H-Index: 8
Last. Li Sun (CPU: China Pharmaceutical University)H-Index: 21
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Adipocytes make up the major component of breast tissue, accounting for 90% of stromal tissue. Thus, the crosstalk between adipocytes and breast cancer cells may play a critical role in cancer progression. Adipocyte-breast cancer interactions have been considered important for the promotion of breast cancer metastasis. However, the specific mechanisms underlying these interactions are unclear. In this study, we investigated the mechanisms of adipocyte-mediated breast cancer metastasis. Breast ca...
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#1Nazanin Fathi (Tabriz University of Medical Sciences)H-Index: 7
#2Golnaz Rashidi (Ahvaz Jundishapur University of Medical Sciences)H-Index: 1
Last. Simin Sharifi (Tabriz University of Medical Sciences)H-Index: 25
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Abstract Several studies have processed conceivable evidence for the vital role of Signal Transducer and Activator of Transcription 3 (STAT3) in cancer transformation and carcinogenesis. Therefore, one of the important factors in formation of cancer is STAT3 and for design of novel anticancer drugs is a suitable target. On the other hand, apoptosis pathway has a critical role in the cancers pathogenesis. Generally, increasing developments have been existed to expression, production, phosphorylat...
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#1Stefanie Fruhw眉rth (Sahlgrenska University Hospital)H-Index: 1
#2Heike VogelH-Index: 29
Last. Kevin Jon Williams (TU: Temple University)H-Index: 62
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Obesity has become a worldwide health problem, but we still do not understand the molecular mechanisms that contribute to overeating and low expenditure of energy. Leptin has emerged as a major regulator of energy balance through its actions in the hypothalamus. Importantly, obese people exhibit high circulating levels of leptin, yet the hypothalamus no longer responds normally to this hormone to suppress appetite or to increase energy expenditure. Several well-known hypotheses have been propose...
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#1Marta Szyszka (Poznan University of Medical Sciences)H-Index: 10
#2Marianna Tyczewska (Poznan University of Medical Sciences)H-Index: 13
Last. Marcin Rucinski (Poznan University of Medical Sciences)H-Index: 21
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: Results of studies on the expression of leptin and its receptors in the human prostate gland and human prostate cell lines are contradictory. Regarding this, we carefully reinvestigated this issue using human normal prostate (PrEC, PrSC, PrSMC) and prostate cancer (DU145, LNCaP, PC3) cell lines. Expression of leptin receptor isoforms was assessed by qPCR while the effects of leptin on cell proliferative activity was determined by real-time cell analyzer (RTCA). Expression of the leptin recepto...
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#1Yunxiu Huang (CQMU: Chongqing Medical University)H-Index: 6
#2Qianni Jin (CQMU: Chongqing Medical University)H-Index: 5
Last. Bing Li (CQMU: Chongqing Medical University)H-Index: 1
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Background Previously, it has been shown that obesity may be considered as a risk factor for breast cancer in postmenopausal women. Leptin, a hormone whose level is elevated in obesity, has been suggested to be involved in the development of breast cancer, and univariate survival analyses have shown that over-expression of ACAT2, an enzyme that is involved in the production of cholesteryl esters, may be associated with a poor prognosis. Here, we aimed to investigate the effect of leptin on the p...
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#1Michael J. Barry (Harvard University)H-Index: 111
#2Leigh H. Simmons (Harvard University)H-Index: 9
More than any other cancer, prostate cancer screening with the prostate-specific antigen (PSA) tests increases the risk a man will have to face a diagnosis of prostate cancer. The best evidence from screening trials suggests a small but finite benefit from prostate cancer screening in terms of prostate cancer鈥搒pecific mortality, about 1 fewer prostate cancer death per 1000 men screened over 10 years. The more serious harms of prostate cancer screening, such as erectile dysfunction and incontinen...
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#1Hongzhi Du (CPU: China Pharmaceutical University)H-Index: 9
#2Mao Pang (SYSU: Sun Yat-sen University)H-Index: 1
Last. Li Sun (CPU: China Pharmaceutical University)H-Index: 21
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Abstract Collagen is not only the most abundant protein providing the scaffold for assembly of the extracellular matrix (ECM), but also considered to be the 鈥渉ighway鈥 for cancer cell migration and invasion depending on the different collagen organizations. The accumulation of stabilized collagen is enhanced by different covalent collagen cross-links, lysyl hydroxylases 2 (encoded by the PLOD2 gene) is the key enzyme mediating the formation of the stabilized collagen cross-link. Interestingly, PL...
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#1Jeong Won Park (LMB: Laboratory of Molecular Biology)H-Index: 14
#2Li Zhao (LMB: Laboratory of Molecular Biology)H-Index: 17
Last. Sheue-yann Cheng (LMB: Laboratory of Molecular Biology)H-Index: 53
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Compelling epidemiologic evidence indicates that obesity is a risk factor for human cancers, including breast. However, molecular mechanisms by which obesity could contribute to the development of breast cancer remain unclear. To understand the impact of obesity on breast cancer development, we used a mutant mouse that expresses a mutated thyroid hormone receptor 尾 (denoted as PV) with haplodeficiency of the Pten gene (ThrbPV/PVPten+/- mice). We previously showed that adult nulliparous female Th...
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