TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target
Abstract
High expression or aberrant activation of epidermal growth factor receptor (EGFR) is related to tumor progression and therapy resistance across cancer types, including non-small cell lung cancer (NSCLC). EGFR tyrosine kinase inhibitors (TKIs) are first-line therapy for NSCLC. However, patients eventually deteriorate after inevitable acquisition of EGFR TKI-resistant mutations, highlighting the need for therapeutics with alternative mechanisms of...
Paper Details
Title
TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target
Published Date
Jul 21, 2020
Journal
Volume
11
Issue
1
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