Targeting EMT in Cancer with Repurposed Metabolic Inhibitors

Epithelial-to-mesenchymal transition (EMT), an embryonic phenotypic plasticity program, in cancer confers invasiveness, dissemination, and chemo/immunotherapy resistance.EMT drives through dynamic intermediate states (partial EMT), which possess high metastasis-initiating potential. Genomic and functional analyses have determined the existence of EMT/partial EMT features in multiple human cancer types.EMT is associated with significant metabolic...