Sodium activates human monocytes via the NADPH oxidase and isolevuglandin formation

Prior studies have focused on the role of the kidney and vasculature in salt-induced modulation of blood pressure; however, recent data indicate that sodium accumulates in tissues and can activate immune cells. We sought to examine mechanisms by which salt causes activation of human monocytes both in vivo and in vitro.To study the effect of salt in human monocytes, monocytes were isolated from volunteers to perform several in vitro experiments....