Ascites-induced compression alters the peritoneal microenvironment and promotes metastatic success in ovarian cancer
Abstract
The majority of women with recurrent ovarian cancer (OvCa) develop malignant ascites with volumes that can reach > 2 L. The resulting elevation in intraperitoneal pressure (IPP), from normal values of 5 mmHg to as high as 22 mmHg, causes striking changes in the loading environment in the peritoneal cavity. The effect of ascites-induced changes in IPP on OvCa progression is largely unknown. Herein we model the functional consequences of...
Paper Details
Title
Ascites-induced compression alters the peritoneal microenvironment and promotes metastatic success in ovarian cancer
Published Date
Jul 17, 2020
Journal
Volume
10
Issue
1
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