Basket trials: From tumour gnostic to tumour agnostic drug development
Abstract
Molecular profiling provides the insight that specific genetic alterations can be detected across a wide range of different histologically characterised tumour types. Thus, the basic concept of basket trials (BTs) to target those genetic alterations with the same anti-tumour agents independent of the underlying tumour type was tumour agnostic. BTs can be divided into tumour gnostic, tumour semi-gnostic, and tumour agnostic trials which cover BTs...
Paper Details
Title
Basket trials: From tumour gnostic to tumour agnostic drug development
Published Date
Nov 1, 2020
Journal
Volume
90
Pages
102082 - 102082
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