The purinergic P2X7 receptor as a potential drug target to combat neuroinflammation in neurodegenerative diseases
Abstract
Neurodegenerative diseases (NDDs) represent a huge social burden, particularly in Alzheimer's disease (AD) in which all proposed treatments investigated in murine models have failed during clinical trials (CTs). Thus, novel therapeutic strategies remain crucial. Neuroinflammation is a common pathogenic feature of NDDs. As purinergic P2X7 receptors (P2X7Rs) are gatekeepers of inflammation, they could be developed as drug targets for NDDs. Herein,...
Paper Details
Title
The purinergic P2X7 receptor as a potential drug target to combat neuroinflammation in neurodegenerative diseases
Published Date
Jul 16, 2020
Journal
Volume
40
Issue
6
Pages
2427 - 2465
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