Erythrocyte-targeted immunomodulatory antigens enabled by in vivo selection of D-peptides

Published: Jul 15, 2020
Abstract
Targeting of antigens to erythrocytes can be used to selectively mitigate their immunogenicity, but the methods to equip a variety of cargoes with erythrocyte-targeting properties are limited. Here we identified a D-peptide that targets murine erythrocytes and decreases anti-drug antibody responses when conjugated to the protective antigen from Bacillus anthracis, a protein of therapeutic interest. The D-peptide likewise decreases inflammatory...
Paper Details
Title
Erythrocyte-targeted immunomodulatory antigens enabled by in vivo selection of D-peptides
Published Date
Jul 15, 2020
Journal
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