In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement
Abstract
Poly(ADP-ribose) polymerase (PARP) enzymes use nicotinamide adenine dinucleotide (NAD+) to modify up to seven different amino acids with a single mono(ADP-ribose) unit (MARylation deposited by PARP monoenzymes) or branched poly(ADP-ribose) polymers (PARylation deposited by PARP polyenzymes). To enable the development of tool compounds for PARP monoenzymes and polyenzymes, we have developed active site probes for use in in vitro and cellular...
Paper Details
Title
In Vitro and Cellular Probes to Study PARP Enzyme Target Engagement
Published Date
Jul 1, 2020
Journal
Volume
27
Issue
7
Pages
877 - 887.e14
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Notes
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