Dynamic regulatory module networks for inference of cell type-specific transcriptional networks - input data

Published on Apr 14, 2022in bioRxiv
· DOI :10.1101/2020.07.18.210328
Fotuhi Siahpirani1
Estimated H-index: 1
(UW: University of Wisconsin–Madison),
Estimated H-index: 1
(UW: University of Wisconsin–Madison)
+ 5 AuthorsRoy1
Estimated H-index: 1
Changes in transcriptional regulatory networks can significantly alter cell fate. To gain insight into transcriptional dynamics, several studies have profiled transcriptomes and epigenomes at different stages of a developmental process. However, integrating these data across multiple cell types to infer cell type specific regulatory networks is a major challenge because of the small sample size for each time point. We present a novel approach, Dynamic Regulatory Module Networks (DRMNs), to model regulatory network dynamics on a cell lineage. DRMNs represent a cell type specific network by a set of expression modules and associated regulatory programs, and probabilistically model the transitions between cell types. DRMNs learn a cell type9s regulatory network from input expression and epigenomic profiles using multi-task learning to exploit cell type relatedness. We applied DRMNs to study regulatory network dynamics in two null different developmental dynamic processes including cellular reprogramming and liver dedifferentiation. For both systems, DRMN predicted relevant regulators driving the major patterns of expression in each time point as well as regulators for transitioning gene sets that change their expression over time.
Cited By1
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