Invasive non-typeable Haemophilus influenzae infection due to endometritis associated with adenomyosis

Published on Jul 16, 2020in BMC Infectious Diseases2.688
· DOI :10.1186/S12879-020-05193-2
Yoshito Nishimura5
Estimated H-index: 5
(Okayama University),
Hideharu Hagiya13
Estimated H-index: 13
(Okayama University)
+ 9 AuthorsFumio Otsuka35
Estimated H-index: 35
(Okayama University)
BACKGROUND The widespread administration of the Haemophilus influenzae type b vaccine has led to the predominance of non-typable H. influenzae (NTHi). However, the occurrence of invasive NTHi infection based on gynecologic diseases is still rare. CASE PRESENTATION A 51-year-old Japanese woman with a history of adenomyoma presented with fever. Blood cultures and a vaginal discharge culture were positive with NTHi. With the high uptake in the uterus with 67Ga scintigraphy, she was diagnosed with invasive NTHi infection. In addition to antibiotic administrations, a total hysterectomy was performed. The pathological analysis found microabscess formations in adenomyosis. CONCLUSIONS Although NTHi bacteremia consequent to a microabscess in adenomyosis is rare, this case emphasizes the need to consider the uterus as a potential source of infection in patients with underlying gynecological diseases, including an invasive NTHi infection with no known primary focus.
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