Role of Telomeres and Telomeric Proteins in Human Malignancies and Their Therapeutic Potential
Abstract
Telomeres are the ends of linear chromosomes comprised of repetitive nucleotide sequences in humans. Telomeres preserve chromosomal stability and genomic integrity. Telomere length shortens with every cell division in somatic cells, eventually resulting in replicative senescence once telomere length becomes critically short. Telomere shortening can be overcome by telomerase enzyme activity that is undetectable in somatic cells, while being...
Paper Details
Title
Role of Telomeres and Telomeric Proteins in Human Malignancies and Their Therapeutic Potential
Published Date
Jul 14, 2020
Journal
Volume
12
Issue
7
Pages
1901 - 1901
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Notes
History