In vivo human brain expression of histone deacetylases in bipolar disorder
Abstract
The etiology of bipolar disorder (BD) is unknown and the neurobiological underpinnings are not fully understood. Both genetic and environmental factors contribute to the risk of BD, which may be linked through epigenetic mechanisms, including those regulated by histone deacetylase (HDAC) enzymes. This study measures in vivo HDAC expression in individuals with BD for the first time using the HDAC-specific radiotracer [11C]Martinostat. Eleven...
Paper Details
Title
In vivo human brain expression of histone deacetylases in bipolar disorder
Published Date
Jul 8, 2020
Journal
Volume
10
Issue
1
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