Cancer cells educate natural killer cells to a metastasis-promoting cell state
Abstract
Natural killer (NK) cells have potent antitumor and antimetastatic activity. It is incompletely understood how cancer cells escape NK cell surveillance. Using ex vivo and in vivo models of metastasis, we establish that keratin-14+ breast cancer cells are vulnerable to NK cells. We then discovered that exposure to cancer cells causes NK cells to lose their cytotoxic ability and promote metastatic outgrowth. Gene expression comparisons revealed...
Paper Details
Title
Cancer cells educate natural killer cells to a metastasis-promoting cell state
Published Date
Jul 9, 2020
Journal
Volume
219
Issue
9
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