Combination of organocatalytic oxidation of alcohols and organolithium chemistry (RLi) in aqueous media, at room temperature and under aerobic conditions.

Published on Aug 6, 2020in Chemical Communications5.996
· DOI :10.1039/D0CC03768K
David Elorriaga2
Estimated H-index: 2
(University of Oviedo),
María J. Rodríguez-Álvarez9
Estimated H-index: 9
(University of Oviedo)
+ 5 AuthorsJoaquín García-Álvarez30
Estimated H-index: 30
(University of Oviedo)
A tandem protocol to access tertiary alcohols has been developed which combines the organocatalytic oxidation of secondary alcohols to ketones followed by their chemoselective addition by several RLi reagents. Reactions take place at room temperature, under air and in aqueous solutions, a trio of conditions that are typically forbidden in polar organometallic chemistry.
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