Rhodojaponin II inhibits TNF‐α‐induced inflammatory cytokine secretion in MH7A human rheumatoid arthritis fibroblast‐like synoviocytes

Rhodojaponin II (R‐II) has been shown to possess anti‐inflammatory activity. Herein, we aimed to explore the effect of R‐II on tumor necrosis factor‐α (TNF‐α)‐induced inflammation in MH7A rheumatoid arthritis (RA) fibroblast‐like synoviocytes (FLSs). We found that R‐II treatment at high concentration suppressed the viability of MH7A cells. R‐II suppressed the levels of nitric oxide and prostaglandin E2, and inhibited messenger RNA expression and...