Combined Fasting Serum C4 and Primary Bile Acids From a Single Stool Sample to Diagnose Bile Acid Diarrhea

Bile acid diarrhea (BAD) can affect up to 33% of patients with diarrhea-predominant irritable bowel syndrome (IBS-D). 1 Wedlake L. et al. Aliment Pharmacol Ther. 2009; 30: 707-717 Crossref PubMed Scopus (260) Google Scholar In the United States, the 48-hour fecal BA test is the gold standard diagnostic test for BAD. Fasting serum 7a-hydroxy-4-cholesten-3-one (C4) measures the product of the rate-limiting step of hepatic BA synthesis and...